Palliative care in oncology frequently falls short in addressing refractory cancer pain and the profound existential distress that arises in advanced illness. Ketamine, a dissociative anesthetic and NMDA receptor antagonist, is increasingly recognized for its rapid antidepressant and analgesic effects, offering unique promise within integrative and naturopathic frameworks. This session examines the pharmacology, protocols, and clinical applications of ketamine in cancer-related pain and emotional suffering, with a focus on ethical, safe, and effective integration into palliative care.

Participants will gain a deeper understanding of ketamine’s mechanisms in pain modulation, neuroinflammation, and neuroplasticity, and explore how adjunctive naturopathic modalities—such as adaptogens, omega-3 fatty acids, mindfulness, and somatic therapies—can enhance therapeutic outcomes. Practical case studies will highlight IM and IV protocols for pain and mood, as well as the innovative use of stellate ganglion block (SGB) with ketamine for autonomic dysregulation and trauma. The presentation will emphasize informed consent, safety screening, and integration planning, while addressing pharmacokinetic and pharmacodynamic considerations relevant to naturopathic physicians with prescriptive authority.